Investigating the Potential of Polyethylene Glycols in Solubilization of Imidazole Drugs of Interest
نویسنده
چکیده
Objective: The study aimed to solubilization of imidazole drugs of interest; ketoconazole (KT) and miconazole nitrate (MN), for enhancement of the water solubility, the dissolution properties and the antimycotic activity of these drugs. Method: Different solid dispersion methods were used to prepare various dispersion systems of KT and MN using polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000) as water-soluble carriers. The prepared systems were evaluated for their physiochemical and dissolution properties and their antimycotic activities. Results: The result obtained showed that the crystallinity of the imidazole drugs was almost lost and a greater amount of drug found in an amorphous state. Dissolution studies proved that the prepared systems showed an improvement in the dissolution of their drug comparing by that of their drug intact and this improvement was progressed as the fractional and molecular weights of PEGs increased. Further, the systems prepared by melting method showed higher dissolution profile than their corresponding systems prepared by evaporation method. The results showed that the aqueous solutions of both KT-PEGs and MN-PEGs systems showed superior antimycotic activity to their drug intact. Conclusion: The solid dispersion of imidazole drugs, KT or MN, with each of PEG 4000 and PEG 6000, using either evaporation or melting method, could be used as a potential drug delivery system for solubilization of imidazole drugs
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